The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice.

@article{Su1998TheCG,
  title={The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice.},
  author={Zao-zhong Su and Malavi T Madireddi and Jie Jessie Lin and Charles S. H. Young and Shinichi Kitada and John C. Reed and Neil I. Goldstein and Paul B Fisher},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 24},
  pages={14400-5}
}
A differentiation induction subtraction hybridization strategy is being used to identify and clone genes involved in growth control and terminal differentiation in human cancer cells. This scheme identified melanoma differentiation associated gene-7 (mda-7), whose expression is up-regulated as a consequence of terminal differentiation in human melanoma cells. Forced expression of mda-7 is growth inhibitory toward diverse human tumor cells. The present studies elucidate the mechanism by which… CONTINUE READING

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