The cancer COMPASS: navigating the functions of MLL complexes in cancer.

@article{Ford2015TheCC,
  title={The cancer COMPASS: navigating the functions of MLL complexes in cancer.},
  author={David J Ford and Andrew K. Dingwall},
  journal={Cancer genetics},
  year={2015},
  volume={208 5},
  pages={178-91}
}
The mixed-lineage leukemia family of histone methyltransferases (MLL1-4, or KMT2A-D) were previously linked to cancer through the founding member, MLL1/KMT2A, which is often involved in translocation-associated gene fusion events in childhood leukemias. However, in recent years, a multitude of tumor exome sequencing studies have revealed that orthologues MLL3/KMT2C and MLL2/KMT2D are mutated in a significant percentage of a large variety of malignancies, particularly solid tumors. These… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS