The calpain-calpastatin system and protein degradation in fusing myoblasts.

@article{Barnoy1998TheCS,
  title={The calpain-calpastatin system and protein degradation in fusing myoblasts.},
  author={Sivia Barnoy and Tova Glaser and Nechama S. Kosower},
  journal={Biochimica et biophysica acta},
  year={1998},
  volume={1402 1},
  pages={52-60}
}
Calpain (Ca(2+)-activated cysteine protease) induced proteolysis has been suggested to play a role in myoblast fusion. We previously found that calpastatin (the endogenous inhibitor of calpain) diminishes markedly in myoblasts during myoblast differentiation just prior to the start of fusion, allowing Ca(2+)-induced calpain activation at that stage. Here, we show that a limited degradation of some proteins occurs within the myoblasts undergoing fusion, but not in proliferating myoblasts. The… CONTINUE READING