The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner.

@article{Yan1996TheCP,
  title={The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner.},
  author={Chunli Yan and Allan Zijian Zhao and J Kelley Bentley and Joseph A. Beavo},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 41},
  pages={25699-706}
}
We report here the identification of cDNAs for three new mouse PDE1C splice variants and the characterization of their kinetics, regulation by Ca2+, sensitivities to inhibitors, and tissue/cellular expression patterns. Sequence analysis indicated that these three cDNAs (PDE1C1, PDE1C4, and PDE1C5), together with our previously reported PDE1C2 and PDE1C3, are alternative splice products of the PDE1C gene. The results from RNase protection analysis and in situ hybridization indicated that the… CONTINUE READING
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