The calmodulin-binding domain in the mouse type 1 inositol 1,4,5-trisphosphate receptor.

@article{Yamada1995TheCD,
  title={The calmodulin-binding domain in the mouse type 1 inositol 1,4,5-trisphosphate receptor.},
  author={Masato Yamada and Atsushi Miyawaki and Kyuichi Saito and Terumi Nakajima and Miki Yamamoto-Hino and Yamada Ryo and Teiichi Furuichi and Katsuhiko Mikoshiba},
  journal={The Biochemical journal},
  year={1995},
  volume={308 ( Pt 1)},
  pages={83-8}
}
We determined the amino acid sequence responsible for the calmodulin (CaM)-binding ability of mouse type 1 Ins(1,4,5)P3 receptor (IP3R1). We expressed various parts of IP3R1 from deleted cDNA and examined their CaM-binding ability. It was shown that the sequence stretching from Lys-1564 to Arg-1585 is necessary for the binding. The full-length IP3R1 with replacement of Trp-1576 by Ala lost its CaM-binding ability. Antibody against residues 1564-1585 of IP3R1 inhibited cerebellar IP3R1 from… CONTINUE READING
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