The calcium-signalling saga: tap water and protein crystals

  title={The calcium-signalling saga: tap water and protein crystals},
  author={Ernesto Carafoli},
  journal={Nature Reviews Molecular Cell Biology},
Of the approximately 1,400 grams of calcium that are in the human body, less than 10 grams manage to escape being trapped in the skeleton and teeth. These few grams might be an insignificant quantity, but they are extraordinarily significant qualitatively. They circulate in the blood and extracellular spaces, and penetrate cells to regulate their most important activities. 

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