The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport.

@article{Vanhouten2004TheCR,
  title={The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport.},
  author={Joshua N Vanhouten and Pamela R Dann and Grace McGeoch and Edward Meigs Brown and K. Krapcho and Margaret C. Neville and John J. Wysolmerski},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={113 4},
  pages={598-608}
}
The transfer of calcium from mother to milk during lactation is poorly understood. In this report, we demonstrate that parathyroid hormone-related protein (PTHrP) production and calcium transport in mammary epithelial cells are regulated by extracellular calcium acting through the calcium-sensing receptor (CaR). The CaR becomes expressed on mammary epithelial cells at the transition from pregnancy to lactation. Increasing concentrations of calcium, neomycin, and a calcimimetic compound suppress… CONTINUE READING