The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland.

@article{Ardeshirpour2006TheCR,
  title={The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland.},
  author={Laleh Ardeshirpour and Pamela R Dann and Martin Pollak and John J. Wysolmerski and Joshua N Vanhouten},
  journal={Bone},
  year={2006},
  volume={38 6},
  pages={787-93}
}
Lactating mammals must supply large amounts of calcium to the mammary gland where it is transported across mammary epithelial cells and into milk. This demand for calcium is associated with transient loss of bone mass, triggered, in part, by the secretion of parathyroid hormone-related protein (PTHrP) from the mammary gland into the circulation. The calcium-sensing receptor (CaR) is a G-protein-coupled receptor that signals in response to extracellular calcium ions. It is responsible for… CONTINUE READING
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