The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis.

@article{Renkema2009TheCR,
  title={The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis.},
  author={Kirsten Y. Renkema and Ana Veli{\'c} and Henry B. P. M. Dijkman and Sjoerd A. J. Verkaart and Annemiete W C M van der Kemp and Marta Nowik and Kim Timmermans and Alain Doucet and Carsten A Wagner and Ren{\'e} J M Bindels and Joost G J Hoenderop},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2009},
  volume={20 8},
  pages={1705-13}
}
Hypercalciuria increases the risk for urolithiasis, but renal adaptive mechanisms reduce this risk. For example, transient receptor potential vanilloid 5 knockout (TPRV5(-/-)) mice lack kidney stones despite urinary calcium (Ca(2+)) wasting and hyperphosphaturia, perhaps as a result of their significant polyuria and urinary acidification. Here, we investigated the mechanisms linking hypercalciuria with these adaptive mechanisms. Exposure of dissected mouse outer medullary collecting ducts to… CONTINUE READING

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