The calcium-chelating capability of tetrahydrofuranic moieties modulates the cytotoxicity of annonaceous acetogenins.

@article{Liaw2011TheCC,
  title={The calcium-chelating capability of tetrahydrofuranic moieties modulates the cytotoxicity of annonaceous acetogenins.},
  author={C C Liaw and Wen-Ying Liao and Chien-Sheng Chen and Shu-chuan Jao and Yang-Chang Wu and Chia-Ning Shen and Shih-Hsiung Wu},
  journal={Angewandte Chemie},
  year={2011},
  volume={50 34},
  pages={7885-91}
}
Annonaceous acetogenins (AGEs) are potential phytochemicals of herbal medicines and exhibit a wide variety of biological activities. Recent work has demonstrated that AGEs have a cytotoxic potency comparable to that of Taxol. AGEs belong to a unique class of polyketides with a C35 or C37 aliphatic chain terminated by an a,b-unsaturated g-lactone group on… CONTINUE READING