The calcium channel blocker nitrendipine attenuates renal and glomerular hypertrophy in diabetic rats.

@article{Nielsen1999TheCC,
  title={The calcium channel blocker nitrendipine attenuates renal and glomerular hypertrophy in diabetic rats.},
  author={Birgitte Herbert Nielsen and Henning Gronbaek and R Osterby and Hans Orskov and Allan Flyvbjerg},
  journal={Experimental nephrology},
  year={1999},
  volume={7 3},
  pages={242-50}
}
The efficacy of the calcium channel blocker nitrendipine in preventing early renal and glomerular hypertrophy and increased urinary albumin excretion (UAE) was studied in experimental diabetes in rats, starting treatment at the onset of diabetes. Female Wistar rats were randomised into four groups: diabetic and non-diabetic rats were given either placebo or nitrendipine (250 mg/kg) in the diet for 8 weeks. After 8 weeks the kidneys in the diabetic animals had increased significantly compared to… CONTINUE READING

Similar Papers

Loading similar papers…