The calcium-calmodulin system: participation in the regulation of steroidogenesis at different stages of granulosa cell differentiation.

@article{Carnegie1984TheCS,
  title={The calcium-calmodulin system: participation in the regulation of steroidogenesis at different stages of granulosa cell differentiation.},
  author={J. A. Carnegie and Benjamin K Tsang},
  journal={Biology of reproduction},
  year={1984},
  volume={30 2},
  pages={
          515-22
        }
}
The involvement of the calcium-calmodulin system in the gonadotropic regulation of granulosa cell steroidogenesis during follicular development was assessed by comparing the effects of agents known to alter calcium metabolism or calmodulin activity on gonadotropin-stimulated progesterone production by rat granulosa cells at different stages of cellular differentiation. Granulosa cells from pregnant mare's serum gonadotropin-injected rats (PMSG-cells) could be stimulated to produce steroids by… 
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TLDR
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TLDR
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TLDR
It is concluded that the calcium ionophore A23187 and (Bu)2cAMP have similar as well as distinct effects on progesterone production in rat granulosa cells in vitro.
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TLDR
The findings indicate that the stimulatory action of luteinization stimulator depends on the transport of calcium ions through voltage-sensitive calcium channels and is modulated by alteration of intracellular calcium levels.
Calcium Ions Positively Modulate Follicle-Stimulating Hormone- and Exogenous Cyclic 3',5'-Adenosine Monophosphate-Driven Transcription of the P450scc Gene in Porcine Granulosa Cells.
TLDR
The ability of Ca2+ to regulate: 1) transcriptional activity of a transiently transfected luciferase reporter gene driven by a 2.32-kb 5′-upstream fragment of the porcine P 450scc gene promoter region; and 2) accumulation of endogenous P450scc transcripts in primary monolayer cultures of porCine granulosa cells is quantitated.
Follicle-stimulating hormone modulation of phosphoinositide turnover in the immature rat Sertoli cell in culture.
TLDR
It is demonstrated that FSH, via formation of cAMP, exerts inhibitory effects on the PI turnover of the Sertoli cell, at the same time FSH inhibits the Ca++-, phospholipid-dependent pathway.
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