The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells

@article{Barbet2008TheCN,
  title={The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells},
  author={Ga{\"e}tan Barbet and Marie Demion and Ivan C Moura and Nicolas Serafini and Thibaut L{\'e}ger and François Vrtovsnik and Renato C Monteiro and Romain Guinamard and J -M. Kinet and Pierre Launay},
  journal={Nature Immunology},
  year={2008},
  volume={9},
  pages={1148-1156}
}
Dendritic cell (DC) maturation and migration are events critical for the initiation of immune responses. After encountering pathogens, DCs upregulate the expression of costimulatory molecules and subsequently migrate to secondary lymphoid organs. Calcium (Ca2+) entry governs the functions of many hematopoietic cell types, but the role of Ca2+ entry in DC biology remains unclear. Here we report that the Ca2+-activated nonselective cation channel TRPM4 was expressed in and controlled the Ca2… CONTINUE READING

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The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

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