The calcineurin activity profiles of cyclosporin and tacrolimus are different in stable renal transplant patients

@article{KoefoedNielsen2006TheCA,
  title={The calcineurin activity profiles of cyclosporin and tacrolimus are different in stable renal transplant patients},
  author={P. Koefoed-Nielsen and N. Karamperis and C. H{\o}jskov and J. Poulsen and K. J{\o}rgensen},
  journal={Transplant International},
  year={2006},
  volume={19}
}
  • P. Koefoed-Nielsen, N. Karamperis, +2 authors K. Jørgensen
  • Published 2006
  • Medicine
  • Transplant International
  • Cyclosporin and tacrolimus remain the cornerstone immunosuppressive drugs in organ transplantation. Dosing and monitoring these drugs is based on pharmacokinetic protocols, but measuring a pharmacodynamic parameter, calcineurin phosphatase (CaN) activity, could be a valuable supplement in determining optimal doses. Forty stable renal transplant patients were investigated three times in a 6‐month period. Blood samples were drawn at 0, 1, 2, 3 and 4 h after oral intake of tacrolimus (FK) or… CONTINUE READING
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