The calcineurin activity profiles of cyclosporin and tacrolimus are different in stable renal transplant patients

  title={The calcineurin activity profiles of cyclosporin and tacrolimus are different in stable renal transplant patients},
  author={P. Koefoed-Nielsen and N. Karamperis and C. H{\o}jskov and J. Poulsen and K. J{\o}rgensen},
  journal={Transplant International},
  • P. Koefoed-Nielsen, N. Karamperis, +2 authors K. Jørgensen
  • Published 2006
  • Medicine
  • Transplant International
  • Cyclosporin and tacrolimus remain the cornerstone immunosuppressive drugs in organ transplantation. Dosing and monitoring these drugs is based on pharmacokinetic protocols, but measuring a pharmacodynamic parameter, calcineurin phosphatase (CaN) activity, could be a valuable supplement in determining optimal doses. Forty stable renal transplant patients were investigated three times in a 6‐month period. Blood samples were drawn at 0, 1, 2, 3 and 4 h after oral intake of tacrolimus (FK) or… CONTINUE READING
    15 Citations

    Paper Mentions

    Interventional Clinical Trial
    Primary Nephrotic Syndrome(pNS) accounts for approximately 90% of the total number of NS in childhood and it is the most common glomerular disease in children. Although treatment with… Expand
    ConditionsNephrotic Syndrome in Children
    T-Cell Receptor-Stimulated Calcineurin Activity Is Inhibited in Isolated T Cells from Transplant Patients
    • 5
    • PDF
    Early conversion from cyclosporine to tacrolimus increases renal graft function in chronic allograft nephropathy at BANFF stages I and II
    • 9


    Blood Tacrolimus Levels and Calcineurin Phosphatase Activity Early after Renal Transplantation
    • 38
    Pharmacodynamic approach to immunosuppressive therapies using calcineurin inhibitors and mycophenolate mofetil.
    • 53
    • PDF
    Validation of the calcineurin phosphatase assay.
    • 23
    • PDF
    The temporal profile of calcineurin inhibition by cyclosporine in vivo.
    • 311
    Immunophilins may limit calcineurin inhibition by cyclosporine and tacrolimus at high drug concentrations.
    • 89
    • Highly Influential
    Efficacy and safety of tacrolimus compared with cyclosporin A microemulsion in renal transplantation: 2 year follow-up results.
    • B. Kraemer, G. Montagnino, +12 authors M. Arias
    • Medicine
    • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
    • 2005
    • 105
    • PDF
    Pharmacodynamic monitoring of immunosuppressive drugs.
    • 48
    • PDF