The calcineurin-NFAT axis controls allograft immunity in myeloid-derived suppressor cells through reprogramming T cell differentiation.

@article{Wang2015TheCA,
  title={The calcineurin-NFAT axis controls allograft immunity in myeloid-derived suppressor cells through reprogramming T cell differentiation.},
  author={Xiao Qin Wang and Yujing Bi and Lixiang Xue and Jiongbo Liao and Xi Chen and Yun Lu and Zhengguo Zhang and Jian Wang and Huanrong Liu and Hui Yang and Guangwei Liu},
  journal={Molecular and cellular biology},
  year={2015},
  volume={35 3},
  pages={598-609}
}
While cyclosporine (CsA) inhibits calcineurin and is highly effective in prolonging rejection for transplantation patients, the immunological mechanisms remain unknown. Herein, the role of calcineurin signaling was investigated in a mouse allogeneic skin transplantation model. The calcineurin inhibitor CsA significantly ameliorated allograft rejection. In CsA-treated allograft recipient mice, CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs) were functional suppressive immune modulators… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS