The calcineurin/nuclear factor of activated T cells signaling pathway regulates osteoclastogenesis in RAW264.7 cells.

@article{Hirotani2004TheCF,
  title={The calcineurin/nuclear factor of activated T cells signaling pathway regulates osteoclastogenesis in RAW264.7 cells.},
  author={Hiroaki Hirotani and Nathaniel A. Tuohy and J E Woo and Paula H. Stern and Neil A. Clipstone},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 14},
  pages={13984-92}
}
Although best known for its role in T lymphocyte activation, the calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway is also known to be involved in a wide range of other biological responses in a variety of different cell types. Here we have investigated the role of the calcineurin/NFAT signaling pathway in the regulation of osteoclast differentiation. Osteoclasts are bone-resorbing multinucleated cells that are derived from the monocyte/macrophage cell lineage after… CONTINUE READING
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