The calcemic response to PTH in the rat: effect of elevated PTH levels and uremia.

@article{Bover1994TheCR,
  title={The calcemic response to PTH in the rat: effect of elevated PTH levels and uremia.},
  author={Jordi Bover and Adam Jara and P Trinidad and Mariano Rodr{\'i}guez and Alejandro Mart{\'i}n-Malo and Arnold J. Felsenfeld},
  journal={Kidney international},
  year={1994},
  volume={46 2},
  pages={310-7}
}
Secondary hyperparathyroidism (2 degrees HPT) is a consistent finding in renal failure. A decreased calcemic response (CR) to parathyroid hormone (PTH) contributes to the development of 2 degrees HPT. Since parathyroidectomy (PTX) corrects the decreased CR to PTH in azotemic animals, down-regulation of PTH receptors induced by an elevation of PTH has been advanced as an important factor in the development of 2 degrees HPT. The goal of the study was to determine in azotemic rats whether a… CONTINUE READING