The cag pathogenicity island of Helicobacter pylori is disrupted in the majority of patient isolates from different human populations.

@article{Kauser2004TheCP,
  title={The cag pathogenicity island of Helicobacter pylori is disrupted in the majority of patient isolates from different human populations.},
  author={Farhana Kauser and A A Khan and Mohamed A. Hussain and Ian M Carroll and Naheed Ahmad and Santosh Tiwari and Yogesh S Shouche and Bimal Das and Mahfooz Alam and Shaik Mahaboob Ali and Chittoor Mohammed Habibullah and R Vasquez Sierra and Francis M{\'e}graud and Leonardo A. Sechi and Niyaz Ahmed},
  journal={Journal of clinical microbiology},
  year={2004},
  volume={42 11},
  pages={5302-8}
}
The cag pathogenicity island (cag-PAI) is one of the major virulence determinants of Helicobacter pylori. The chromosomal integrity of this island or the lack thereof is speculated to play an important role in the progress of the gastroduodenal pathology caused by H. pylori. We determined the integrity of the cag-PAI by using specific flanking and internally anchored PCR primers to know the biogeographical distribution of strains carrying fully integral cag-PAI with proinflammatory behavior in… CONTINUE READING

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