The cadherin switch in ovarian high-grade serous carcinoma is associated with disease progression

@article{Quattrocchi2011TheCS,
  title={The cadherin switch in ovarian high-grade serous carcinoma is associated with disease progression},
  author={Livia Quattrocchi and Andrew R. Green and Stewart G Martin and Lindy Durrant and Suha Deen},
  journal={Virchows Archiv},
  year={2011},
  volume={459},
  pages={21-29}
}
Ovarian high-grade serous carcinoma (HGSC) often has a poor prognosis because of late presentation, lack of sensitivity and specificity of screening modalities and the development of chemoresistance. New targeted therapy is required if survival in these cases is to improve. The profile of E-, P- and N-cadherins in ovarian cancer and its association with survival remain poorly understood. Reduced expression of E-cadherin in prostate cancer associated with increase in the expression of N- and P… CONTINUE READING

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