The cGMP-dependent protein kinase-gene, protein, and function

  title={The cGMP-dependent protein kinase-gene, protein, and function},
  author={Elke Butt and J{\"o}rg Geiger and Thomas Jarchau and Suzanne M. Lohmann and Ulrich Walter},
  journal={Neurochemical Research},
The 30 years of research since the initial discovery of cGMP in urine (1) have demonstrated that a) cGMP is a physiologically important intracellular second messenger for a variety of first messengers (e.g. hormones, autacoids, drugs, toxins, and other regulatory agents), and that b) cGMP achieves its physiological effects by regulating a variety of enzymes and proteins including cGMP-gated ion channels, cGMP-regulated phosphodiesterases, and cGMP-dependent protein kinases (2-8). Substantial… CONTINUE READING
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