The cDNA sequence of a type II cytoskeletal keratin reveals constant and variable structural domains among keratins

@article{Hanukoglu1983TheCS,
  title={The cDNA sequence of a type II cytoskeletal keratin reveals constant and variable structural domains among keratins},
  author={Israel Hanukoglu and E. Fuchs},
  journal={Cell},
  year={1983},
  volume={33},
  pages={915-924}
}
  • Israel Hanukoglu, E. Fuchs
  • Published 1983
  • Biology, Medicine
  • Cell
  • We present the cDNA and amino acid sequences of a cytoskeletal keratin from human epidermis (Mr = 56K) that belongs to one of the two classes of keratins (Type I and Type II) present in all vertebrates. In these two types of keratins the central approximately 300 residue long regions share approximately 30% homology both with one another and with the sequences of other IF proteins. Within this region, all IF proteins are predicted to contain four helical domains demarcated from one another by… CONTINUE READING
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