The cDNA sequence of a human epidermal keratin: Divergence of sequence but conservation of structure among intermediate filament proteins

@article{Hanukoglu1982TheCS,
  title={The cDNA sequence of a human epidermal keratin: Divergence of sequence but conservation of structure among intermediate filament proteins},
  author={Israel Hanukoglu and E. Fuchs},
  journal={Cell},
  year={1982},
  volume={31},
  pages={243-252}
}
  • Israel Hanukoglu, E. Fuchs
  • Published 1982
  • Biology, Medicine
  • Cell
  • We have determined the DNA sequence of a cloned cDNA that is complementary to the mRNA for the 50 kilodalton (kd) human epidermal keratin. This provides the first amino acid sequence for a cytoskeletal keratin. Comparison of this sequence with those of other keratins reveals an evolutionary relationship between the cytoskeletal and the microfibrillar keratins, but shows no homology to matrix or feather keratins. The 50 kd keratin shares 28%-30% homology with partial sequences of other… CONTINUE READING
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