The cDNA sequence of a human epidermal keratin: Divergence of sequence but conservation of structure among intermediate filament proteins
@article{Hanukoglu1982TheCS, title={The cDNA sequence of a human epidermal keratin: Divergence of sequence but conservation of structure among intermediate filament proteins}, author={Israel Hanukoglu and E. Fuchs}, journal={Cell}, year={1982}, volume={31}, pages={243-252} }
We have determined the DNA sequence of a cloned cDNA that is complementary to the mRNA for the 50 kilodalton (kd) human epidermal keratin. This provides the first amino acid sequence for a cytoskeletal keratin. Comparison of this sequence with those of other keratins reveals an evolutionary relationship between the cytoskeletal and the microfibrillar keratins, but shows no homology to matrix or feather keratins. The 50 kd keratin shares 28%-30% homology with partial sequences of other… CONTINUE READING
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References
SHOWING 1-10 OF 70 REFERENCES
Comparison of the proteins of two immunologically distinct intermediate-sized filaments by amino acid sequence analysis: desmin and vimentin.
- Medicine, Biology
- Proceedings of the National Academy of Sciences of the United States of America
- 1981
- 113
- Highly Influential
- PDF
The evolution and complexity of the genes encoding the cytoskeletal proteins of human epidermal cells.
- Biology, Medicine
- Current problems in dermatology
- 1983
- 10
Two distinct classes of keratin genes and their evolutionary significance
- Biology, Medicine
- Cell
- 1981
- 264
- PDF
Intermediate filaments of baby hamster kidney (BHK-21) cells and bovine epidermal keratinocytes have similar ultrastructures and subunit domain structures.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1980
- 102
- PDF
Structure of the three-chain unit of the bovine epidermal keratin filament.
- Chemistry, Medicine
- Journal of molecular biology
- 1978
- 102
- Highly Influential
The polypeptide composition of bovine epidermal alpha-keratin.
- Chemistry, Medicine
- The Biochemical journal
- 1975
- 115
The genes coding for the cytoskeletal proteins actin and vimentin in warm‐blooded vertebrates.
- Medicine, Biology
- The EMBO journal
- 1982
- 113
Related amino acid sequences in neurofilaments and non-neuronal intermediate filaments
- Medicine, Biology
- Nature
- 1982
- 101
- Highly Influential
Mammalian cytoplasmic actins are the products of at least two genes and differ in primary structure in at least 25 identified positions from skeletal muscle actins.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1978
- 240
- PDF