The cDNA sequence of a human epidermal keratin: Divergence of sequence but conservation of structure among intermediate filament proteins

@article{Hanukoglu1982TheCS,
  title={The cDNA sequence of a human epidermal keratin: Divergence of sequence but conservation of structure among intermediate filament proteins},
  author={Israel Hanukoglu and Elaine Fuchs},
  journal={Cell},
  year={1982},
  volume={31},
  pages={243-252}
}
We have determined the DNA sequence of a cloned cDNA that is complementary to the mRNA for the 50 kilodalton (kd) human epidermal keratin. This provides the first amino acid sequence for a cytoskeletal keratin. Comparison of this sequence with those of other keratins reveals an evolutionary relationship between the cytoskeletal and the microfibrillar keratins, but shows no homology to matrix or feather keratins. The 50 kd keratin shares 28%-30% homology with partial sequences of other… Expand

Paper Mentions

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Proteopedia entry: Coiled‐coil structure of keratins
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TLDR
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Isolation and characterization of a cDNA clone coding for human epidermal keratin K5. Sequence of the carboxyterminal half of this keratin.
A cDNA clone encoding human epidermal keratin No. 5 (K5) has been isolated from a lambda gt10 cDNA library on the basis of crosshybridization with cDNAs coding for other basic keratins andExpand
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