The cDNA‐deduced primary structure of human sex hormone‐binding globulin and location of its steroid‐binding domain

@article{Hammond1987TheCP,
  title={The cDNA‐deduced primary structure of human sex hormone‐binding globulin and location of its steroid‐binding domain},
  author={G. Hammond and D. A. Underhill and C. L. Smith and I. Goping and M. Harley and N. Musto and C. Y. Cheng and C. W. Bardin},
  journal={FEBS Letters},
  year={1987},
  volume={215}
}
We have sequenced a cDNA for sex hormone‐binding globulin (SHBG) isolated from a phage λgt 11 human liver cDNA library. The library was screened with a radiolabeled rat androgen‐binding protein (ABP) cDNA, and the abundance of SHBG cDNAs was 1 in 750 000 plaques examined. The largest human SHBG cDNA (1194 base‐pairs) contained a reading frame for 381 amino acids. This comprised 8 amino acids of a signal peptide followed by 373 residues starting with the known NH2‐terminal sequence of human SHBG… Expand
130 Citations
Sex hormone-binding globulin/androgen-binding protein: Steroid-binding and dimerization domains
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