The cAMP response element binding protein, CREB, is a potent inhibitor of diverse transcriptional activators.

@article{Lemaigre1993TheCR,
  title={The cAMP response element binding protein, CREB, is a potent inhibitor of diverse transcriptional activators.},
  author={F. P. Lemaigre and Christopher I Ace and Michael R. Green},
  journal={Nucleic acids research},
  year={1993},
  volume={21 12},
  pages={2907-11}
}
Cyclic AMP response element binding protein (CREB) activates transcription of cAMP response element (CRE)-containing promoters following an elevation of intracellular cAMP. Here we show that CREB and the highly related protein ATF-1 are also potent transcription inhibitors. Strikingly, CREB inhibits transcription of multiple activators, whose DNA-binding… CONTINUE READING