The cAMP receptor CAR4 regulates axial patterning and cellular differentiation during late development of Dictyostelium.

@article{Louis1994TheCR,
  title={The cAMP receptor CAR4 regulates axial patterning and cellular differentiation during late development of Dictyostelium.},
  author={J Mestichelli Louis and Genadi Ginsburg and Alan R. Kimmel},
  journal={Genes & development},
  year={1994},
  volume={8 17},
  pages={
          2086-96
        }
}
Pseudoplasmodia of developing Dictyostelium are organized with anteroposterior polarity. We have isolated CAR4, the gene for a new cell-surface, G protein-linked cAMP receptor. CAR4 mRNA is initially expressed during tip elongation and continues to accumulate into culmination. CAR4 is maximally expressed in pseudoplasmodia anteriors which are centers for extracellular cAMP signaling and for organization of cellular patterning. Although car4 null cells progress unperturbed through early… CONTINUE READING
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