The cAMP effectors PKA and Epac activate endothelial NO synthase through PI3K/Akt pathway in human endothelial cells.

@article{GarcaMorales2017TheCE,
  title={The cAMP effectors PKA and Epac activate endothelial NO synthase through PI3K/Akt pathway in human endothelial cells.},
  author={Ver{\'o}nica Garc{\'i}a-Morales and Mar{\'i}a Luaces-Regueira and Manuel Campos-Toimil},
  journal={Biochemical pharmacology},
  year={2017},
  volume={145},
  pages={94-101}
}
3',5'-Cyclic adenosine monophosphate (cAMP) exerts an endothelium-dependent vasorelaxant action by stimulating endothelial NO synthase (eNOS) activity, and the subsequent NO release, through cAMP protein kinase (PKA) and exchange protein directly activated by cAMP (Epac) activation in endothelial cells. Here, we have investigated the mechanism by which the cAMP-Epac/PKA pathway activates eNOS. cAMP-elevating agents (forskolin and dibutyryl-cAMP) and the joint activation of PKA (6-Bnz-cAMP) and… CONTINUE READING
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