The cAMP binding protein Epac regulates cardiac myofilament function.

  title={The cAMP binding protein Epac regulates cardiac myofilament function.},
  author={Olivier Cazorla and Alexandre Lucas and Florence Poirier and Alain Lacampagne and Frank Lezoualc'h},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 33},
In the heart, cAMP is a key regulator of excitation-contraction coupling and its biological effects are mainly associated with the activity of protein kinase A (PKA). The aim of this study was to investigate the contribution of the cAMP-binding protein Epac (Exchange protein directly activated by cAMP) in the regulation of the contractile properties of rat ventricular cardiac myocytes. We report that both PKA and Epac increased cardiac sarcomere contraction but through opposite mechanisms… CONTINUE READING
28 Citations
37 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 28 extracted citations


Publications referenced by this paper.
Showing 1-10 of 37 references

Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy

  • C Ulucan
  • Am J Physiol Heart Circ Physiol
  • 2007
1 Excerpt

Similar Papers

Loading similar papers…