The c-myc gene is a direct target of mammalian SWI/SNF-related complexes during differentiation-associated cell cycle arrest.

@article{Nagl2006TheCG,
  title={The c-myc gene is a direct target of mammalian SWI/SNF-related complexes during differentiation-associated cell cycle arrest.},
  author={Norman G. Nagl and Daniel R. Zweitzig and Bayar Thimmapaya and George R Beck and Elizabeth Moran},
  journal={Cancer research},
  year={2006},
  volume={66 3},
  pages={1289-93}
}
The activity of mammalian SWI/SNF-related chromatin remodeling complexes is crucial for differentiation, development, and tumor suppression. Cell cycle-regulating activities dependent on the complexes include induction of the p21(WAF1/CIP1) kinase inhibitor and repression of E2F-responsive promoters. These responses are linked through effects on pRb phosphorylation, but the direct role of the SWI/SNF-related complexes in their regulation is not fully understood. Results presented here reveal… CONTINUE READING

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