The c-myc gene encodes superimposed RNA polymerase II and III promoters.

@article{Chung1987TheCG,
  title={The c-myc gene encodes superimposed RNA polymerase II and III promoters.},
  author={Jeannie H Chung and Daniel J Sussman and Rolf Zeller and Philip Leder},
  journal={Cell},
  year={1987},
  volume={51 6},
  pages={1001-8}
}
The first exon of the c-myc gene has unusual properties that suggest some further role in gene regulation. It encodes a large, evolutionarily conserved leader exon that is transcribed more frequently than the remaining exons of the c-myc gene. In what follows, we provide a possible explanation for these observations. We find that the major promoter of the c-myc gene is bifunctional; that is, it supports transcription by RNA polymerases II and III (pol II and III). Both enzymes initiate in vitro… CONTINUE READING

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