The c-erb B-2 proto-oncogene in human pancreatic cancer.

  title={The c-erb B-2 proto-oncogene in human pancreatic cancer.},
  author={Peter A. Hall and Ciara M Hughes and Sally Staddon and Paul I Richman and William J. Gullick and Nick R. Lemoine},
  journal={The Journal of pathology},
  volume={161 3},
The c-erb B-2 oncogene encodes a 190 kD transmembrane growth factor receptor which is closely related to the EGF receptor and has been found to be amplified and overexpressed in a number of human adenocarcinomas, particularly of the breast. We have analysed, by immunocytochemistry using the 21N antibody, expression of c-erb B-2 in a retrospective series of pancreatic adenocarcinoma, chronic pancreatitis, and examples of histologically normal pancreas. In three cases (21 per cent) of chronic… CONTINUE READING