The c-Yes 3'-UTR contains adenine/uridine-rich elements that bind AUF1 and HuR involved in mRNA decay in breast cancer cells.

@article{Sommer2005TheC3,
  title={The c-Yes 3'-UTR contains adenine/uridine-rich elements that bind AUF1 and HuR involved in mRNA decay in breast cancer cells.},
  author={Stephanie Sommer and Yukun Cui and Gary Brewer and Suzanne A W Fuqua},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2005},
  volume={97 3},
  pages={219-29}
}
c-Yes is a member of the c-Src family of tyrosine kinases and has been implicated in intracellular signaling, cell morphology, and adhesion. Changes in its expression have also been associated with the aggressiveness of human breast and colon cancer cells. In MDA-MB-231 human breast cancer cells, overexpression of the small heat shock protein 27 (hsp27) results in a downregulation of c-Yes levels, concomitant with increased in vitro invasiveness and in vivo metastatic behavior. Very little is… CONTINUE READING

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