The c-MYC-AP4-p21 cascade.

  title={The c-MYC-AP4-p21 cascade.},
  author={Peter Jung and Heiko Hermeking},
  journal={Cell cycle},
  volume={8 7},
The p21 gene encodes a CDK-inhibitor, which is induced by p53 and many other anti-proliferative factors. The mechanism of transcriptional repression of p21 by c-MYC has been a subject of intensive study for several years, as it may explain how c-MYC promotes cell cycle progression. Recently, we reported a novel mechanism which allows c-MYC to repress p21: c-MYC triggers a transcriptional cascade by directly inducing the gene encoding the bHLH-LZ transcription factor AP4 (TFAP4), which binds to… CONTINUE READING
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