The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia.

@article{Okuno2004TheCN,
  title={The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia.},
  author={Shuzo Okuno and Atsushi Saito and Takeshi Hayashi and Pak Hoo Chan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 36},
  pages={7879-87}
}
The c-Jun N-terminal protein kinase (JNK) signaling pathway is implicated in neuronal apoptosis. The mechanism by which activated JNK induces neuronal apoptosis is strongly linked to mitochondrial apoptogenic proteins, although the molecular machinery downstream of JNK has not been precisely elucidated. Our study examined the relevance of proapoptotic Bcl-2 family members in JNK-mediated apoptosis after transient focal cerebral ischemia (tFCI), which, when induced by 60 min of middle cerebral… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 108 extracted citations

Phosphorylation of c-Jun in avian and mammalian motoneurons in vivo during programmed cell death: an early reversible event in the apoptotic cascade.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2005
View 7 Excerpts
Highly Influenced

Cerebral ischemia and neuroregeneration

Neural regeneration research • 2018
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 35 references

A critical role of neural-specific JNK3 for ischemic apoptosis.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 3 Excerpts
Highly Influenced

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 4 Excerpts
Highly Influenced

Interaction between XIAP and Smac/DIABLO in the mouse brain after transient focal cerebral ischemia.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2003
View 2 Excerpts

Similar Papers

Loading similar papers…