The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression.

@article{Faris1998TheCN,
  title={The c-Jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression.},
  author={Mary Faris and Niels C.T. Kokot and Kevin M. Latinis and Shailaja Kasibhatla and Douglas R Green and Gary A Koretzky and Andr{\'e} Nel},
  journal={Journal of immunology},
  year={1998},
  volume={160 1},
  pages={134-44}
}
T lymphocytes undergo apoptosis in response to cellular stress, including UV exposure and gamma irradiation. However, the mechanism by which stress stimuli induce apoptosis is not well understood. While stress stimuli induce the activation of the c-Jun N-terminal kinase (JNK) pathway, it is not clear whether the JNK cascade is activated as a result of cell death or whether the cascade participates in inducing apoptosis. Using a Jurkat T cell line transfected with dominant active (DA)-mitogen… CONTINUE READING

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