The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases.

  title={The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases.},
  author={Niloy Roy and Quinn L. Deveraux and Ryosuke Takahashi and Guy Salvesen and John C. Reed},
  journal={The EMBO journal},
  volume={16 23},
The inhibitor of apoptosis (IAP) family of proteins are highly conserved through evolution. However, the mechanisms by which these proteins interfere with apoptotic cell death have been enigmatic. Recently, we showed that one of the human IAP family proteins, XIAP, can bind to and potently inhibit specific cell death proteases (caspases) that function in the distal portions of the proteolytic cascades involved in apoptosis. In this study, we investigated three of the other known members of the… CONTINUE READING
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