The c-Abl tyrosine kinase controls protein kinase Cδ-induced Fli-1 phosphorylation in human dermal fibroblasts.

@article{Bujor2011TheCT,
  title={The c-Abl tyrosine kinase controls protein kinase Cδ-induced Fli-1 phosphorylation in human dermal fibroblasts.},
  author={Andreea M. Bujor and Yoshihide Asano and P. E. Haines and Robert Lafyatis and Maria Trojanowska},
  journal={Arthritis and rheumatism},
  year={2011},
  volume={63 6},
  pages={1729-37}
}
OBJECTIVE We have previously demonstrated that in response to transforming growth factor β (TGFβ), Fli-1 activity is repressed through a series of sequential posttranslational modifications, consisting of protein kinase Cδ (PKCδ)-induced Thr312 phosphorylation, acetylation by p300/CREB binding protein-associated factor, and detachment from the collagen promoter. The purpose of this study was to further investigate the upstream events that lead to Fli-1 phosphorylation in response to TGF… CONTINUE READING

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