The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death.

@article{Xiao2011TheCS,
  title={The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death.},
  author={Lei Xiao and Dongxing Chen and Peng Hu and Junbing Wu and Weizhe Liu and Yanhong Zhao and Mou Cao and Yuan Fang and Wenzhi Bi and Zheng Zheng and Jian Ren and Guangju Ji and Yan Wang and Zengqiang Yuan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 26},
  pages={
          9611-9
        }
}
Oxidative stress influences cell survival and homeostasis, but the mechanisms underlying the biological effects of oxidative stress remain to be elucidated. The protein kinase MST1 (mammalian Ste20-like kinase 1) plays a major role in oxidative stress-induced cell death in primary mammalian neurons. However, the mechanisms that regulate MST1 in oxidative stress responses remain largely unknown. In the present study, we demonstrate that the protein kinase c-Abl phosphorylates MST1 at Y433, which… CONTINUE READING

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