The burgeoning family of unconventional T cells

@article{Godfrey2015TheBF,
  title={The burgeoning family of unconventional T cells},
  author={Dale I. Godfrey and Adam P. Uldrich and James McCluskey and Jamie Rossjohn and D. Branch Moody},
  journal={Nature Immunology},
  year={2015},
  volume={16},
  pages={1114-1123}
}
While most studies of T lymphocytes have focused on T cells reactive to complexes of peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do not fit this paradigm. These include CD1-restricted T cells, MR1-restricted mucosal associated invariant T cells (MAIT cells), MHC class Ib–reactive T cells, and γδ T cells. Collectively, these T cells are considered 'unconventional', in part because they can recognize lipids, small-molecule metabolites and specially… Expand
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