The budding yeast mei5 and sae3 proteins act together with dmc1 during meiotic recombination.

  title={The budding yeast mei5 and sae3 proteins act together with dmc1 during meiotic recombination.},
  author={Hideo Tsubouchi and G. Shirleen Roeder},
  volume={168 3},
Here we provide evidence that the Mei5 and Sae3 proteins of budding yeast act together with Dmc1, a meiosis-specific, RecA-like recombinase. The mei5 and sae3 mutations reduce sporulation, spore viability, and crossing over to the same extent as dmc1. In all three mutants, these defects are largely suppressed by overproduction of Rad51. In addition, mei5 and sae3, like dmc1, suppress the cell-cycle arrest phenotype of the hop2 mutant. The Mei5, Sae3, and Dmc1 proteins colocalize to foci on… CONTINUE READING
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