The bromodomain protein LEX-1 acts with TAM-1 to modulate gene expression in C. elegans

@article{Tseng2007TheBP,
  title={The bromodomain protein LEX-1 acts with TAM-1 to modulate gene expression in C. elegans},
  author={Rong-Jeng Tseng and Kristin R. Armstrong and Xiaodong Wang and Helen M. Chamberlin},
  journal={Molecular Genetics and Genomics},
  year={2007},
  volume={278},
  pages={507-518}
}
In many organisms, repetitive DNA serves as a trigger for gene silencing. However, some gene expression is observed from repetitive genomic regions such as heterochromatin, suggesting mechanisms exist to modulate the silencing effects. From a genetic screen in C. elegans, we have identified mutations in two genes important for expression of repetitive sequences: lex-1 and tam-1. Here we show that lex-1 encodes a protein containing an ATPase domain and a bromodomain. LEX-1 is similar to the… CONTINUE READING