The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells

Abstract

The long-lived latent HIV-1 reservoir is the major barrier for complete cure of Acquired Immune Deficiency Syndrome (AIDS). Here we report that a novel bromodomain and extraterminal domain (BET) inhibitor bromosporine which can broadly target BETs, is able to potently reactivate HIV-1 replication in different latency models alone and more powerful when… (More)
DOI: 10.18632/oncotarget.21585

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Cite this paper

@inproceedings{Pan2017TheBA, title={The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells}, author={Hanyu Pan and Panpan Lu and Yinzhong Shen and Yanan Wang and Zhengtao Jiang and Xinyi Yang and Yangcheng Zhong and He Yang and Inam Ulla Khan and Muya Zhou and Bokang Li and Ziyu Zhang and Jian-qing Xu and Hongzhou Lu and Huanzhang Zhu}, booktitle={Oncotarget}, year={2017} }