The bromodomain: from epigenome reader to druggable target.

  title={The bromodomain: from epigenome reader to druggable target.},
  author={Roberto Sanchez and Jamel Meslamani and Ming-Ming Zhou},
  journal={Biochimica et biophysica acta},
  volume={1839 8},
Lysine acetylation is a fundamental post-translational modification that plays an important role in the control of gene transcription in chromatin in an ordered fashion. The bromodomain, the conserved structural module present in transcription-associated proteins, functions exclusively to recognize acetyl-lysine on histones and non-histone proteins. The structural analyses of bromodomains' recognition of lysine-acetylated peptides derived from histones and cellular proteins provide detailed… CONTINUE READING

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