The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer.

@article{Yang2020TheBS,
  title={The broad spectrum antiviral ivermectin targets the host nuclear transport importin $\alpha$/$\beta$1 heterodimer.},
  author={Sundy N. Y. Yang and Sarah C Atkinson and Chunxiao Wang and Alexander Lee and Marie A. Bogoyevitch and Natalie A. Borg and David Andrew Jans},
  journal={Antiviral research},
  year={2020},
  pages={
          104760
        }
}
Infection by RNA viruses such as human immunodeficiency virus (HIV)-1, influenza, and dengue virus (DENV) represent a major burden for human health worldwide. Although RNA viruses replicate in the infected host cell cytoplasm, the nucleus is central to key stages of the infectious cycle of HIV-1 and Influenza, and an important target of DENV nonstructural protein 5 (NS5) in limiting the host antiviral response. We previously identified the small molecule ivermectin as an inhibitor of HIV-1… Expand
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