The breast mucin MUCI as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer.

@article{Regimbald1996TheBM,
  title={The breast mucin MUCI as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer.},
  author={L H Regimbald and Linda M. Pilarski and Bryan Michael Longenecker and Mark A. Reddish and Gabrielle L. Zimmermann and Judith Hugh},
  journal={Cancer research},
  year={1996},
  volume={56 18},
  pages={4244-9}
}
The MUC 1 mucin is expressed on normal breast epithelium and in 90% of breast cancers. We report here that tumor-associated MUC1 is a ligand for intercellular adhesion molecule 1 (ICAM-1). Antibodies to ICAM-1 and to MUC1 inhibited adhesion of human and transfected mouse MUC1-positive cell lines to human umbilical vein endothelial cell monolayers and immobilized recombinant human ICAM-1-immunoglobulin fusion protein. Purified MUC1 pretreatment of recombinant human ICAM-1 was an equally… CONTINUE READING

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American Association for Cancer cancerres.aacrjournals.org Downloaded from 1996;56:4244-4249

  • K. Iwai, H. Ishikura, +5 authors Research
  • AACR Publications Research. on August
  • 1996
2 Excerpts

Episialin ( MUC 1 ) inhibits cytotoxic lymphocytetarget cell interaction

  • E. van de Wiel-van Kemmenade, M. J. L. Ligtenberg, +5 authors C. G. Figdor
  • Immunology
  • 1993

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