The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk

  title={The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk},
  author={Johan W. Jonker and Gracia Merino and Sandra Musters and Antonius E. van Herwaarden and Ellen Bolscher and E. B. Wagenaar and Elly M Mesman and Trevor C Dale and Alfred H Schinkel},
  journal={Nature Medicine},
Contamination of milk with drugs, pesticides and other xenotoxins can pose a major health risk to breast-fed infants and dairy consumers. Here we show that the multidrug transporter BCRP (encoded by ABCG2) is strongly induced in the mammary gland of mice, cows and humans during lactation and that it is responsible for the active secretion of clinically and toxicologically important substrates such as the dietary carcinogen PhIP, the anticancer drug topotecan and the antiulcerative cimetidine… CONTINUE READING
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