The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk

@article{Jonker2005TheBC,
  title={The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk},
  author={Johan W. Jonker and Gracia Merino and Sandra Musters and Antonius E. van Herwaarden and Ellen Bolscher and E. B. Wagenaar and Elly M Mesman and Trevor C Dale and Alfred H Schinkel},
  journal={Nature Medicine},
  year={2005},
  volume={11},
  pages={127-129}
}
Contamination of milk with drugs, pesticides and other xenotoxins can pose a major health risk to breast-fed infants and dairy consumers. Here we show that the multidrug transporter BCRP (encoded by ABCG2) is strongly induced in the mammary gland of mice, cows and humans during lactation and that it is responsible for the active secretion of clinically and toxicologically important substrates such as the dietary carcinogen PhIP, the anticancer drug topotecan and the antiulcerative cimetidine… CONTINUE READING
Highly Influential
This paper has highly influenced 17 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 142 extracted citations

The ABCG2 Efflux Transporter in the Mammary Gland Mediates Veterinary Drug Secretion across the Blood-Milk Barrier into Milk of Dairy Cows.

Drug metabolism and disposition: the biological fate of chemicals • 2016
View 9 Excerpts
Highly Influenced

Role of STAT5 and epigenetics in lactation-associated upregulation of multidrug transporter ABCG2 in the mammary gland.

American journal of physiology. Endocrinology and metabolism • 2014
View 3 Excerpts
Highly Influenced

References

Publications referenced by this paper.

N at ur e P ub lis hi ng G ro up ht tp :// w w w .n at ur e

X Wang
Mol. Pharmacol • 2003

Similar Papers

Loading similar papers…