The breakpoint cluster region site in patients with Philadelphia chromosome-positive chronic myelogenous leukemia. Clinical, laboratory, and prognostic correlations.

@article{Verschraegen1995TheBC,
  title={The breakpoint cluster region site in patients with Philadelphia chromosome-positive chronic myelogenous leukemia. Clinical, laboratory, and prognostic correlations.},
  author={Claire F. Verschraegen and Hagop M Kantarjian and C F Hirsch-Ginsberg and Moon Soo Lee and Susan O'brien and Mary Beth Rios and Sanford A. Stass and Michael Keating and Moshe Talpaz},
  journal={Cancer},
  year={1995},
  volume={76 6},
  pages={992-7}
}
BACKGROUND The breakpoint site of the breakpoint cluster region (bcr) has been correlated with patient characteristics, with the disease phase, and with the prognosis of patients with chronic myelogenous leukemia (CML), but the findings remain controversial. METHODS Appropriate restriction enzymes and the 3' and universal probes were used to map the breakpoint site by Southern blot analysis into 5' and 3' breakpoints and a breakpoint in zone 3 (or fragment 2) in 362 patients in different… CONTINUE READING
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