The breakage–fusion–bridge (BFB) cycle as a mechanism for generating genetic heterogeneity in osteosarcoma

  title={The breakage–fusion–bridge (BFB) cycle as a mechanism for generating genetic heterogeneity in osteosarcoma},
  author={Shamini Selvarajah and Maisa Yoshimoto and Paul C. Park and Georges Maire and Jana Paděrov{\'a} and Jane Bayani and Gloria Lim and Khaldoun Al-Romaih and Jeremy Andrew Squire and Maria Zielenska},
Osteosarcoma (OS) is characterized by chromosomal instability and high copy number gene amplification. The breakage–fusion–bridge (BFB) cycle is a well-established mechanism of genome instability in tumors and in vitro models used to study the origins of complex chromosomal rearrangements and cancer genome amplification. To determine whether the BFB cycle could be increasing the de novo rate of formation of cytogenetic aberrations in OS, the frequency of anaphase bridge configurations and… 

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Running title: Nuclear remodeling and chromosomal rearrangements in Hodgkin's lymphoma

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