The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo.

@article{Lebeurrier2005TheBT,
  title={The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo.},
  author={Nathalie Lebeurrier and G{\'e}raldine Liot and Jos{\'e} P L{\'o}pez-Atalaya and Cyrille Orset and M{\'o}nica Fern{\'a}ndez-Monreal and Peter Sonderegger and Carine Ali and Denis Vivien},
  journal={Molecular and cellular neurosciences},
  year={2005},
  volume={30 4},
  pages={552-8}
}
Considering its brain-specific expression, neuroserpin (NS), a potent inhibitor of tissue-type plasminogen activator (tPA), might be a good therapeutic target to limit the pro-excitotoxic effects of tPA within the cerebral parenchyma, without affecting the benefit from thrombolysis in stroke patients. Here, we aimed at determining the mechanisms of action responsible for the previously reported neuroprotective activity of NS in rodent experimental cerebral ischemia. First, we show in vivo that… CONTINUE READING

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