The brain renin-angiotensin system: localization and general significance.

@article{Bunnemann1992TheBR,
  title={The brain renin-angiotensin system: localization and general significance.},
  author={B H Bunnemann and Kjell Fuxe and Detlev Ganten},
  journal={Journal of cardiovascular pharmacology},
  year={1992},
  volume={19 Suppl 6},
  pages={S51-62}
}
This report summarizes the present data about the existence of components of the renin-angiotensin system in the rat brain. Angiotensinogen mRNA, mas proto-oncogene mRNA, angiotensin II (Ang II), and Ang II receptors have been mapped in the brain by using in situ hybridization, immunocytochemistry, and receptor autoradiography. These markers turned out to be widely distributed throughout the brain and to be not only restricted to areas related to cardiovascular control, but also to be present… CONTINUE READING