The brain mineralocorticoid receptor: greedy for ligand, mysterious in function.

@article{Reul2000TheBM,
  title={The brain mineralocorticoid receptor: greedy for ligand, mysterious in function.},
  author={Johannes M. H. M. Reul and Angela Gesing and Susanne K. Droste and I S Stec and A A Weber and Claude Bachmann and Alicia Bilang-Bleuel and Florian Holsboer and Astrid C. E. Linthorst},
  journal={European journal of pharmacology},
  year={2000},
  volume={405 1-3},
  pages={235-49}
}
Glucocorticoids exert their regulatory effects on the hypothalamic-pituitary-adrenocortical axis via two types of corticosteroid receptors: the glucocorticoid receptor and the mineralocorticoid receptor. Whereas the glucocorticoid receptor has a broad distribution in the brain, highest levels of mineralocorticoid receptor are found in the hippocampus. Based on the differential occupancy profile by endogenous glucocorticoids, glucocorticoid receptors are thought to mediate negative feedback… CONTINUE READING

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