The brain mineralocorticoid receptor: greedy for ligand, mysterious in function.

  title={The brain mineralocorticoid receptor: greedy for ligand, mysterious in function.},
  author={Johannes M. H. M. Reul and Angela Gesing and Susanne K. Droste and I S Stec and A A Weber and Claude Bachmann and Alicia Bilang-Bleuel and Florian Holsboer and Astrid C. E. Linthorst},
  journal={European journal of pharmacology},
  volume={405 1-3},
Glucocorticoids exert their regulatory effects on the hypothalamic-pituitary-adrenocortical axis via two types of corticosteroid receptors: the glucocorticoid receptor and the mineralocorticoid receptor. Whereas the glucocorticoid receptor has a broad distribution in the brain, highest levels of mineralocorticoid receptor are found in the hippocampus. Based on the differential occupancy profile by endogenous glucocorticoids, glucocorticoid receptors are thought to mediate negative feedback… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 73 extracted citations


Publications referenced by this paper.
Showing 1-10 of 122 references

Distribution of the mineralocorticoid and the glucocorticoid receptor mRNAs in the rat hippocampus

  • J.A.M. Van Eekelen, W. Jiang, E. R. De Kloet, M. C. Bohn
  • J. Neurosci. Res
  • 1988
Highly Influential
6 Excerpts

Specificity of the adrenal steroid receptor system in rat

  • H. D. Veldhuis, C. Van Koppen, M. Van Ittersum, E. R. De Kloet
  • hippocampus. Endocrinology
  • 1982
Highly Influential
4 Excerpts

Effects of the high - affinity corticotropin - releasing hormone receptor I antagonist R 121919 in major depression : the first 20 patients treated

  • A. W. Zobel, T. Nickel, +4 authors F. ̈ Holsboer
  • J . Psychiatr . Res .
  • 2000
1 Excerpt

Effects of the high-affinity corticotropin-releasing hormone receptor I antagonist R121919 in major depression: the first 20 patients

  • F. ̈ Holsboer
  • treated. J. Psychiatr. Res
  • 2000

Similar Papers

Loading similar papers…